Located along the western border of Virginia and bisected by Interstate 64, Virgina's Western Highlands is located within a day's drive of a large portion of the East Coast and portions of the Midwest. The following table is a list of selected metropolitan areas and driving times and distances to Virginia's Western Highlands.
| Area | Mileage | Driving Time |
| Baltimore, MD | 230 | 4 Hours |
| Charlotte, NC | 207 | 3.5 Hours |
| Washington DC | 200 | 3.5 Hours |
| Richmond, VA | 175 | 3 Hours |
| Charleston, WV | 140 | 2 Hours |
| Greensboro, NC | 128 | 2.75 Hours |
| Roanoke, VA | 29 | 40 Minutes |
The
region is easily accessible by road, rail, or plane. The area is bisected
by US 220, a major US highway running in a north-south direction, and by
Interstate 64, an east-west interstate highway. Additionally, the southern
portion of Virginia's Western Highlands is a short drive from Interstate
81, Exit 141 via State Route 311. Interstate 81, Exit 150 may also be taken
to access the region via US 220 North through Daleville, Fincastle, and
Eagle Rock VA. From the north, it is also possible to take exit 225 off
Interstate 81 to take US Highway 250 to Monterey in Highland County.
The convenient location of Amtrak in Clifton Forge allows convenient rail
access to the region. Rental car service is available through several
companies in the region.
Commercial air service is available through the Roanoke
Regional Airport (ROA) and through the Greenbrier
Valley Airport (LWB). The Roanoke Regional Airport is a mere 30 miles
from New Castle in the southern portion of the Virginia's Western Highlands.
The Greenbrier Valley Airport is approximately 30 miles from Covington,
VA.
